Microbial conversion of solasodine to 1-androstene-3,17-dione (AD), a key intermediate for androgen synthesis |
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| Authors: | Aniruddha Shukla Shridhar Patil Sudhakar Bharti |
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| Institution: | School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Khandwa Road Campus, Indore-452 001, India |
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| Abstract: | The spirosolane side chain of solasodine has been cleaved by cholesterol preinduced Mycobacterium sp. NRRL B-3805 to yield 1-androstene-3,17-dione (AD), a key intermediate for the synthesis of androgenic drugs. Conversion up to 34% has been recorded in shake flask culture after 192 h incubation period using dimethyl-formamide as carrier for solasodine addition. |
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