Interaction of PARP-2 with DNA structures mimicking DNA repair intermediates and consequences on activity of base excision repair proteins |
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| Authors: | Mikhail M. Kutuzov,Svetlana N. Khodyreva,Jean-Christophe Amé ,Ekaterina S. Ilina,Maria V. Sukhanova,Valé rie Schreiber,Olga I. Lavrik |
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| Affiliation: | 1. Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;2. UMR7242, Biotechnology and Cell Signaling, Université de Strasbourg, CNRS, MEDALIS, ESBS, Illkirch, France;3. Novosibirsk State University, Novosibirsk, Russia |
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| Abstract: | Poly(ADP-ribosyl)ation is a posttranslational protein modification significant for genomic stability and cell survival in response to DNA damage. Poly(ADP-ribosyl)ation is catalyzed by poly(ADP-ribose)polymerases (PARPs). Among the 17 members of the PARP family, PARP-1 and PARP-2 are described as enzymes whose catalytic activity is stimulated by some types of DNA damages. |
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| Keywords: | PARP-1 PARP-2 PARylation Base excision repair DNA polymerase β |
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