首页 | 本学科首页   官方微博 | 高级检索  
     


The stem cell secretome and its role in brain repair
Authors:Denise Drago  Chiara Cossetti  Nunzio Iraci  Edoardo Gaude  Giovanna Musco  Angela Bachi  Stefano Pluchino
Affiliation:1. CNS Repair Unit, Institute of Experimental Neurology, Division of Neurosciences, San Raffaele Scientific Institute, 20132 Milan, Italy;2. Biomolecular Mass Spectrometry Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy;3. John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, and National Institute for Health Research (NIHR), Biomedical Research Centre, University of Cambridge, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK;4. Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0PY, UK;5. Dulbecco Telethon Institute c/o S. Raffaele Scientific Institute, Biomolecular NMR Laboratory, Center for Translational Genomics and Bioinformatics, Milano, Italy
Abstract:Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal (MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and therapeutic effect after transplantation in experimental central nervous system (CNS) disease models through the secretion of immune modulatory or neurotrophic paracrine factors.
Keywords:Secretome   Mesenchymal stem cells   Neural stem cells   Brain repair   Stem cell transplantation
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号