Prostacyclin is not a circulating hormone in man |
| |
Authors: | IA Blair SE Barrow KA Waddell PJ Lewis CT Dollery |
| |
Institution: | Department of Clinical Pharmacology Royal Postgraduate Medical School University of London London W12 OHS, UK |
| |
Abstract: | A highly specific stabel isotope dilution assay for plasma 6-oxo-prostaglandin F1α has been developed. The method employs capillary column gas chromatography coupled with negative ion chemical ionisation mass spectrometry. The limit of sensitivity of the assay is 0.5 pg.ml−1. Concentrations of 6-oxo-prostaglandin F1α in the plasma of 20 healthy volunteers determined by this assay were all below 3 pg.ml−1. The levels were much lower than any previously reported and confirms that prostacyclin is not a circulating hormone in man under normal physiological conditions. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |