Synthesis and bronchospasmolytic properties of some pyridazinone derivatives |
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| Authors: | Stefano Corsano Giovannella Strappaghetti Rossana Scapicchi Olimpia Scalise |
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| Affiliation: | Institute of Pharmaceutic Chemistry, University of Perugia, Via del Liceo-06123 Perugia, Italy |
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| Abstract: | The synthesis and evaluaton of the biological activity of a series of 3(2H)-pyridazinones is reported. The bronchodilatating activity of these compounds was determined on the guinea pig trachea. Compounds 6 and 17 with 1-(4-amino-3,5-dichlorophenyl)-2-hydroxyethyl-and 1-(3,4-dichlorophenyl)-2-hydroxyethyl groups linked through a piperazine ring to the 6-position of 3(2H)-pyridazinone show a good bronchospasmolytic activity. |
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