胰岛素样生长因子IGF系统与鱼类性腺的研究进展

IGFs系统包含3个配体(IGF-1、IGF-2、IGF-3)、2个受体(IGF-1R、IGF-2R)和6个IGF结合蛋白(IGFBP).生殖和生长是生物体最基本的特征,两者既密切相关又相互区别,胰岛素样生长因子(IGFs)是生长轴和生殖轴相交联的关键因子.最近研究表明:鱼类性腺的发育及成熟伴随着细胞分化和组织生长,传统的生长因子IGF-1、IGF-2和最近发现的IGF-3,对鱼类性腺发挥着重要作用.本文重点介绍鱼类特有的配体IGF-3的结构,鱼类IGFs系统的信号通路及其与鱼类性腺的相关性研究进展.

Insulin-Like Growth Factor System and Gonadal Function in Fish

Insulin-like growth factor (IGF) system consists of three ligands (IGF-1, IGF-2, most recently IGF-3), two receptors (IGF-1R, IGF-2R) and six IGF binding proteins (IGFBPs). Reproduction and growth, the most basic characteristics of organisms, are closely related to and distinguished from each other. IGFs are the key factors that regulate growth and reproduction axis. Recent researches have shown that gonadal development and maturation are associated with cell differentiation and tissue growth, and that traditional growth factors IGF-1, IGF-2 and a recently discovered IGF subtype (IGF-3) play an important role in fish gonad. The present review emphasizes the structure of IGF-3, a fish gonad-specific IGF, and IGF signal pathway as well as its potential physiological functions in fish gonad.