Organoelement derivatives of steroids: synthesis and structural characterization of diorganotin chloride adducts of hormones |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India;2. Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India |
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| Abstract: | Ten new diorganotin dichloride adducts of hormones of the type R2SnCl2·2L [where R = Me, Et, n-Bu, Oct and Ph; L = 4-androsten-17ß-ol-3-one (A); 5-androsten-3ß-ol-17-one (B); 4-androsten-17α- methyl-17ß-ol-3-one (C) and 3,17-dihydroxy-5- pregnene-20-one (D)] have been prepared and characterized at 297 K and 223 K. Spectroscopic measurements (IR; Raman; 1H, 13C, 119Sn NMR) suggest the dissociation or fast ligand exchange in solution at 297 K. Hexa-coordinated adducts with bonding through carbonyl oxygen and trans-R groups in octahedral geometry are formulated at 223 K. |
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