Anti-tumor activity of two binuclear gold(I) complexes with bridging dithiolate ligands |
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| Affiliation: | 1. Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy;2. Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale G.B. Morgagni 50, 50134 Firenze, Italy;1. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan;2. Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;3. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, PR China;4. Innovation Center of Nanomedicine, Institute of Industry Promotion-KAWASAKI, 66-20 Horikawa-cho, Saiwai-ku, Kawasaki 212-0013, Japan;5. Centre for Advanced Theranostics, School of Life Sciences, Henan University, Jin Ming Avenue, Kaifeng, Henan 475004, PR China;6. Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan;7. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan;8. Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;9. Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;1. Department of Chemistry, Indian Institute of Technology Patna, Patna 801103, Bihar, India;2. Laboratoire de Photochimie et D''ingenierie Macromoleculaires-EA 4567, Université de Haute-Alsace, Jean-Baptiste Donnet Institute, France |
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| Abstract: | Two new binuclear complexes of gold with bridging dithiolate ligands were synthesized and characterized: (ø3PAu)2(μ-DTE) and (Et3PAu)2(μ-DMTA); H2DTE=dithioerylthritol and H2DMTA=2,5-dimer- capto-1-thia-3,4-diazole. These compounds and three gold compounds with antiarthritic activity (gold sodium thiomalate, gold thioglucose and Et3PAuCl) were tested for antitumor activity using the Ehrlich- Ascites tumor cell in mice. Only (ø3PAu)e(μ-DTE) showed significant activity. |
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