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AMPK in the brain: its roles in energy balance and neuroprotection |
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| Authors: | Gabriele V Ronnett† Santosh Ramamurthy Amy M Kleman Leslie E Landree Susan Aja‡ |
| Institution: | Department of Neuroscience, The Center for Metabolism and Obesity Research (CMOR), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurology, The Center for Metabolism and Obesity Research (CMOR), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA |
| Abstract: | Adenosine monophosphate-activated protein kinase (AMPK) senses metabolic stress and integrates diverse physiological signals to restore energy balance. Multiple functions are indicated for AMPK in the CNS. While all neurons sense their own energy status, some integrate neuro-humoral signals to assess organismal energy balance. A variety of disease states may involve AMPK, so determining the underlying mechanisms is important. We review the impact of altered AMPK activity under physiological (hunger, satiety) and pathophysiological (stroke) conditions, as well as therapeutic manipulations of AMPK that may improve energy balance. |
| Keywords: | AMP-activated protein kinase C75 energy balance neurons obesity stroke |