Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond |
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Authors: | Venkatareddy UdumulaMaruthi Chittapragada Jorden B. MarbleDaniel L. Dayton Young Wan Ham |
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Affiliation: | Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, United States |
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Abstract: | An amino-functionalized 2-deoxystreptamine (2-DOS) mimic was conjugated by an amide bond to a neamine moiety containing a carboxylic acid in ring II. A library of A-site RNA and its mutants was prepared to examine RNA binding characteristics of the additional 2-DOS moiety attached to neamine. The 2-DOS mimic conjugated to the neamine increased binding affinity up to 200-folds compared to that of neamine. The conjugate binds to native A-site RNA and its mutants with up to 6-fold difference in sequence selectivity. |
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Keywords: | 2-Deoxystreptamine mimic Neamine Aminoglycosides RNA recognition |
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