Regulation of the immune response by antibody. I. Suppression of antibody formation and concomitant enhancement of cell-mediated immunity by passive antibody |
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| Authors: | F Y Liew C R Parish |
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| Affiliation: | 1. Facultad de Agronomía y Zootecnia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina;2. INTA EEA Famaillá, Tucumán, Argentina;3. Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Puebla Pue, México |
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| Abstract: | The ability of passively administered antibody to regulate the humoral and cell-mediated immune responses to flagellin, polymerised flagellin, and sheep red blood cell was investigated in rats. It was found that for all three antigens, suppression of antibody formation by passive antibody was accompanied by enhanced delayed-type hypersensitivity. This phenomenon was observed with both homologous and heterologous passive antibody. However, with flagellin and sheep red blood cell, high concentrations of passive antibody led to a decline of delayed-type hypersensitivity.This regulation of immune responses by passive antibody was antigen specific. The delayed-type hypersensitivity induced by antigen in the presence of specific passive antibody persisted for at least 4 weeks after immunisation and was transferable by immune cells but not by serum. |
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