Growth and siderophore production by Bordetella pertussis under iron-restricted conditions |
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Authors: | A.R. Gorringe G. Woods A. Robinson |
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Affiliation: | Biologics Division, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, U.K. |
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Abstract: | It has been demonstrated that under iron-restricted conditions Bordetella pertussis can obtain iron from iron-saturated human transferrin. Direct contact between B. pertussis and transferrin was not required as B. pertussis was able to acquire iron from transferrin when they were separated by a dialysis membrane. Siderophore activity was detected in supernatants from iron-restricted cultures of B. pertussis, B. bronchiseptica and B. parapertussis. Siderophores were identified as hydroxamates and were produced by both virulent and avirulent strains of B. pertussis. |
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Keywords: | Siderophore Bordetella pertussis Iron |
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