A monte carlo approach to population dynamics of cells in a HIV immune response model |
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Authors: | Rachel Mannion Heather J Ruskin R B Pandey |
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Institution: | (1) School of Computer Applications Dublin City University, Dublin 9, Ireland;(2) Department of Physics and Astronomy, University of Southern Mississippi, 39406-5046 Hattiesburg, MS |
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Abstract: | Summary Using a direct Monte Carlo simulation, population growth of helper T-cells (N
H) and viral cells (N
v) is studied for an immune response model with an enhanced spatial inter-cellular interaction relevant to HIV as a function
of viral mutation. In the absence of cellular mobility (P
mob=0), the helper T-cells grow nonmonotonically before reaching saturation and the viral population grows monotonically before
reaching a constant equilibrium. Cellular mobility (P
mob=1) enhances the viral growth and reduces the stimulative T-cell growth. Below a mutation threshold (P
c), the steady-state density of helper T-cell (p
H) is larger than that of the Virus (p
v); the density difference Δp
o(=pV−pH) remains a constant at P
mob=1 while −Δp
o→0 as P
mut→P
c at P
mob=0. Above the mutation threshold, the difference Δp
o in cell density, grows with ΔP=P
mut−P
c monotonically: ΔP
o ∞ (ΔP)β ≃ with β≈0.574±0.016 in absence of mobility, while Δp
o≈6(ΔP) with P
mob=1. |
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Keywords: | asynchronous updating Monte Carlo HIV immune response mutation discrete model |
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