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Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies |
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| Authors: | Radi Marco Angeli Lucilla Franchi Luigi Contemori Lorenzo Maga Giovanni Samuele Alberta Zanoli Samantha Armand-Ugon Mercedes Gonzalez Emmanuel Llano Anuska Esté Jose A Botta Maurizio |
| Affiliation: | Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy. |
| Abstract: | A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results. |
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