|
|||||
|
|
6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors |
|
| Authors: | Bromidge Steven M Bertani Barbara Borriello Manuela Faedo Stefania Gordon Laurie J Granci Enrica Hill Matthew Marshall Howard R Stasi Luigi P Zucchelli Valeria Merlo Giancarlo Vesentini Alessia Watson Jeannette M Zonzini Laura |
| Institution: | Neurosciences CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. steve.bromidge@gsk.com |
| Abstract: | Investigation of a series 6-2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT(1A/1B/1D) receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |