The evolution of peroxisomal and mitochondrial alanine: glyoxylate aminotransferase 1 in mammalian liver |
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| Authors: | Y Takada T Noguchi |
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| Institution: | Department of Biochemistry, Kyushu Dental College, Kitakyushu 803, Japan |
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| Abstract: | Immunological distances of alanine: glyoxylate aminotransferase 1 (serine:pyruvate aminotransferase) in mitochondria or peroxisomes from eight different mammalian liver were determined with rabbit anti-serum against the mitochondrial enzyme of rat liver by microcomplement fixation. Results suggest that heterotopic alanine:glyoxylate aminotransferase 1 are orthologous proteins and their subcellular localization and substrate specificity changed during rapid molecular evolution. |
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| Keywords: | AGT alanine glyoxylate aminotransferase ID immunological distance Myr million years |
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