Yeast ABC transporters-- a tale of sex, stress, drugs and aging |
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| Authors: | Jungwirth Helmut Kuchler Karl |
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| Affiliation: | Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry, Campus Vienna Biocenter; Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria |
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| Abstract: | Yeast ATP-binding cassette (ABC) proteins are implicated in many biological phenomena, often acting at crossroads of vital cellular processes. Their functions encompass peptide pheromone secretion, regulation of mitochondrial function, vacuolar detoxification, as well as pleiotropic drug resistance and stress adaptation. Because yeast harbors several homologues of mammalian ABC proteins with medical importance, understanding their molecular mechanisms, substrate interaction and three-dimensional structure of yeast ABC proteins might help identifying new approaches aimed at combating drug resistance or other ABC-mediated diseases. This review provides a comprehensive discussion on the functions of the ABC protein family in the yeast Saccharomyces cerevisiae. |
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| Keywords: | ABC, ATP-binding cassette PDR, pleiotropic drug resistance MDR, multidrug resistance NBD, nucleotide-binding domain TMS, transmembrane-spanning segment ER, endoplasmatic reticulum MRP, multidrug resistance-related protein CFTR, cystic fibrosis transmembrane conductance regulator NTE, N-terminal extension LCFA, long chain fatty acid PDREs, pleiotropic drug resistance elements |
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