Monoclonal antibodies in solid tumours: approaches to therapy with emphasis on gynaecological cancer |
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Authors: | G Fleckenstein R Osmers and J Puchta |
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Institution: | (1) Department of Gynecology and Obstetrics, University of G?ttingen, Robert-Koch-Strasse 40, 37075, Germany |
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Abstract: | Monoclonal antibodies have progressed from the laboratory to the clinic. Although recognised in diagnosis there are still
problems as far as their therapeutic use is concerned. This review looks at the history, principles of active specific immunotherapy,
clinical experience with monoclonal antibodies in therapy of solid tumours, in particular the development of new bispecific
monoclonal antibodies, and trials in ovarian, breast and colorectal cancer. Immunoconjugates, linked with radionuclides and
cytotoxic drugs, indicate future developments. Conditions for successful therapy, especially with adjuvants in patients with
small tumour residues, are also described. |
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Keywords: | active and passive specific immunotherapy monoclonal antibodies solid tumours bispecific monoclonal antibodies radioimmunoconjugates chemoimmunoconjugates |
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