Inbreeding and the genetic control of nondisjunction |
| |
| Authors: | Shozo Yokoyama Theodore Reich Kenneth Morgan |
| |
| Affiliation: | (1) Department of Psychiatry, Washington University School of Medicine, 216 South Kingshighway, 63110 St. Louis, Missouri, USA;(2) Jewish Hospital of St. Louis, 216 South Kingshighway, 63110 St. Louis, Missouri, USA;(3) Department of Genetics, University of Alberta, T6G 2E9 Edmonton, Alberta, Canada |
| |
| Abstract: | Summary We have studied the frequency of trisomics in newly formed zygotes and the proportion of trisomics, k, coming from consanguineous marriages by assuming that recessive genes at a single locus or multiple loci are responsible for the induction of nondisjunction. For mitotic nondisjunction, the value of k increases as the magnitude of consanguinity of the parents increases, but the opposite relationship holds for meiotic nondisjunction. Therefore, it is important to distinguish mitotic and meiotic types in the genetic study of nondisjunction. This seems to be one of the simples tests for detecting the genetic control of nondisjunction. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
