| 微生物发酵生产丁二酸研究进展 |
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| 引用本文： | 刘嵘明,梁丽亚,吴明科,姜岷.微生物发酵生产丁二酸研究进展[J].生物工程学报,2013,29(10):1386-1397. |
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| 作者姓名： | 刘嵘明 梁丽亚 吴明科 姜岷 |
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| 作者单位： | 南京工业大学 生物与制药工程学院 材料化学工程国家重点实验室，江苏 南京 211816;南京工业大学 生物与制药工程学院 材料化学工程国家重点实验室，江苏 南京 211816;南京工业大学 生物与制药工程学院 材料化学工程国家重点实验室，江苏 南京 211816;南京工业大学 生物与制药工程学院 材料化学工程国家重点实验室，江苏 南京 211816 |
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| 基金项目： | 国家自然科学基金(No. 21076105)，国家重点基础研究发展计划(973计划) (No. 2009CB724701)，江苏高校优势学科建设工程项目资助。 |
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| 摘 要： | 丁二酸是微生物三羧酸循环中重要的代谢中间产物，广泛用于生物高分子、食品与医药等行业，市场潜在需求量巨大。文中从3个方面归纳了国内外生物基丁二酸研究进展：能够过量积累丁二酸的微生物的发现和筛选，产丁二酸工程菌构建中所采用的基因工程策略及代谢工程技术，丁二酸发酵过程控制与优化。最后，讨论了微生物法生产丁二酸今后的研究方向。
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| 关 键 词： | 丁二酸，菌种选育，基因工程，代谢工程，过程强化 |
| 收稿时间： | 2013/6/25 0:00:00 |
Progress in microbial production of succinic acid |
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| Rongming Liu,Liya Liang,Mingke Wu and Min Jiang.Progress in microbial production of succinic acid[J].Chinese Journal of Biotechnology,2013,29(10):1386-1397. |
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| Authors: | Rongming Liu Liya Liang Mingke Wu and Min Jiang |
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| Institution: | State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China |
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| Abstract: | Succinic acid is one of the key intermediates in the tricarboxylic acid cycle (TCA)and has huge potentials in biopolymer, food, medicine applications. This article reviews recent research progress in the production of succinic acid by microbial fermentation, including discovery and screening of the succinic-acid-producing microbes, the progress of genetic engineering strategy and metabolic engineering technology for construction of succinic acid-producing strains, and fermentation process control and optimization. Finally, we discussed the limitation of current progress and proposed the future research needs for microbial production of succinic acid. |
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| Keywords: | succinic acid strain breeding genetic engineering metabolic engineering process control and optimization |
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