Calmodulin binding to human spectrin |
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| Authors: | A Berglund L Backman V P Shanbhag |
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| Institution: | Department of Biochemistry, University of Umeå, S-901-87 Umeå, Sweden |
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| Abstract: | Human hepatocellular carcinoma cells (Hep G2) were shown to secrete apo A-I as a proprotein . No apo A-I synthesis could be detected with endothelial cells from human umbilical cord veins. Conversion of proapo A-I into apo A-I is a slow (of the order of hours) process, mediated by a Ca2+/Mg2+-dependent enzyme which is present on the surface of plasma lipoprotein particles, endothelial cells and Hep G2 cells, and is probably synthesized by Hep G2 cells. |
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| Keywords: | Calmodulin Human spectrin Protein-protein interaction Erythrocyte Aqueous two-phase partition |
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