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Survival of dissociated adrenal chromaffin cells of rat and monkey transplanted into rat brain |
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| Authors: | Urmi Patel-Vaidya M R Wells William J Freed |
| Institution: | (1) Neurochemistry Research, V.A. Medical Center, Washington, USA;(2) Preclinical Neurosciences Section, Neuropsychiatry Branch, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, USA;(3) Preclinical Neurosciences Section, Neuropsychiatry Branch, National Institute of Mental Health, Saint Elizabeths Hospital, 20032 Washington D.C., USA |
| Abstract: | Summary Adrenal chromaffin cells from adult rats and monkeys were mechanically dissociated and implanted into the striatum of adult rats by stereotaxic injection. Rat chromaffin cells survived (5%) and showed differentiation by forming processes 1 h-28 days after implantation. Monkey chromaffin cells survived for 48 h but showed very little formation of processes. The method presented allows rapid nonenzymatic dissociation and transplantation of adrenal medullary cells. |
| Keywords: | Cell dissociation Chromaffin cells Adrenal medulla Tissue transplantation Brain grafts Rat Marmoset monkey |
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