1-(t-Butyldimethylsilyloxy) benzotriazole (TBDMS-OBt): A new and novel reagent for the synthesis of peptides |
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| Authors: | Subramanyam J. Tantry and Vommina V. Suresh Babu |
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| Affiliation: | (1) Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India |
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| Abstract: | Synthesis and use of 1-(t-butyldimethylsilyloxy)benzotriazole (TBDMS-OBt) in the coupling of Fmoc-amino acid chlorides to amino free amino acid esters in homogeneous solution phase is described. The coupling required no addition of base and was fast and racemization free. Work up and isolation of products were easy. Yield, purity and 1H NMR analysis of peptides, synthesised by this method, were satisfactory. |
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| Keywords: | dialkyl amino acids N-methyl amino acids racemization free coupling TBDMS-OBt |
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