Analysis of oscillations in yeast continuous cultures by a new simplified model |
| |
Authors: | Lorenzo Cazzador |
| |
Institution: | (1) LADSEB-CNR, corso Stati Uniti 4, 35020 Padova, Italy |
| |
Abstract: | The autonomous oscillations in yeast continuous cultures are investigated analytically and related to the behaviour of the
single cell by means of a suitable modified version of Monod’s classical chemostat model. Two main cell phases or states are
considered to account for the experimentally observed changes occurring in the cell growth course: the budded phase and the
unbudded one. Thus, a sort of two compartment structure is given to the total biomass. The model so far obtained allows one
to analyse the local properties of the predicted steady states under various assumptions, both on the yield coefficients and
the specific growth rates. Necessary conditions for the local instability are derived and the existence of stable limit cycles
is shown by computer simulation. With respect to the qualitative changes in the metabolic parameters, this analysis agrees
with the results obtained by simulation of complex structured and segregated models. However, the oscillation period is too
long compared with the experimental one and this fact may be mainly due to the strong simplifying assumptions on the dynamic
evolution of the transfer rates between the two compartments. The model’s usefulness seems until now restricted to the identification
of the relationships between the cell cycle regulation and the oscillation triggering. |
| |
Keywords: | |
本文献已被 ScienceDirect SpringerLink 等数据库收录! |
|