肠道微生物在重症急性胰腺炎进展中的作用及其潜在的治疗意义

重症急性胰腺炎是临床常见的消化系统急危重症,起病急、变化快、并发症多、病死率高,但尚无特效疗法,是目前医学界面临的一大难题.近年来,肠道微生物因其在人类健康和疾病中的重要作用而受到越来越多的关注.研究表明,重症急性胰腺炎早期即存在肠道微生物失调,而由胰腺炎引起的菌群失调和菌群移位导致的肠源性感染是影响重症急性胰腺炎严重...

The role of intestinal microbiota in the progression of severe acute pancreatitis and its potential therapeutic implications

Severe acute pancreatitis (SAP) is a clinically common critical disease of digestive system, with acute onset,rapid change,multiple complications and high mortality.To date, there is no especially effective therapy for it,which is a difficult problem faced by the healthcare professionals at present.In recent years,intestinal microbiota has attracted more and more attention because of their important role in human health and diseases.Studies have shown that intestinal microbiota disorders exist in the early stage of SAP,and enterogenicinfection resulted from the imbalance and translocation of microbiota caused by pancreatitis is an important factor affecting the severity and mortality of SAP.Therefore,in depth study on the role of intestinal microorganisms in the progression of SAP is of great significance for further understanding of the pathogenesis of SAP and exploring new strategies of symbiotic microbial coordination to obtain human health benefits.