慢性胰腺炎患者血清总胆固醇和血红蛋白水平与肠道菌群失调的相关性研究

目的 探讨慢性胰腺炎(CP)患者血清总胆固醇(TC)、血红蛋白(Hb)水平与肠道菌群失调的相关性。 方法 选取2014年1月至2019年1月在本院就诊的69例CP患者作为观察组,另选取同期行健康体检者120例作为对照组。记录两组性别、年龄、体质量指数(BMI)、收缩压、舒张压,采用日立7600全自动生化仪检测TC水平,采用CELL DYN1800全自动血细胞分析仪检测Hb水平,采用细菌培养法进行肠道菌群检查。比较两组基线资料、TC、Hb水平及肠道菌群数量差异,采用Spearman相关分析CP患者血清TC、Hb水平与肠道菌群数量的相关性。 结果 两组性别、年龄、BMI、收缩压、舒张压等差异均无统计学意义(P>0.05)。与对照组比较,观察组的血清TC水平较高(P结论 CP患者血清TC、Hb水平异常,且与患者肠道菌群失调密切相关,可为CP的临床治疗提供参考依据。

Correlation between serum levels of total cholesterol and hemoglobin and intestinal flora imbalance in patients with chronic pancreatitis

Objective To explore the correlation between the levels of serum total cholesterol (TC) and hemoglobin (Hb) and intestinal flora imbalance in patients with chronic pancreatitis (CP). Methods Sixty nine CP patients treated in our hospital from January 2014 to January 2019 were selected as the observation group, and another 120 healthy individuals in the same period were selected as the control group.The gender, age, body mass index (BMI), systolic blood pressure and diastolic blood pressure in the two groups were recorded. The level of TC was measured using Hitachi 7600 automatic biochemical instrument, the level of Hb was measured using CELL DYN1800 automatic hematology analyzer, and the intestinal flora was detected with bacterial culturing method. The baseline data, levels of TC and Hb, and the amount of intestinal flora were compared between groups; the correlation between serum TC and Hb levels and the count of intestinal flora in CP patients were analyzed by Spearman correlation. Results There were no significant differences in gender, age, BMI, systolic blood pressure and diastolic blood pressure between the two groups (all P>0.05).Compared with the control group, the level of serum TC was higher (PConclusion The levels of TC and Hb in CP patients are abnormal and closely related to intestinal flora imbalance, which may provide reference for clinical treatment of CP.