| 细菌耐受噬菌体感染的分子机制研究进展 |
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| 引用本文： | 钟卓君,饶贤才,乐率.细菌耐受噬菌体感染的分子机制研究进展[J].微生物学通报,2021,48(9):3249-3260. |
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| 作者姓名： | 钟卓君 饶贤才 乐率 |
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| 作者单位： | 陆军军医大学基础医学院微生物学教研室 重庆 400038 |
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| 基金项目： | 国家自然科学基金（31870167） |
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| 摘 要： | 噬菌体是能感染细菌的病毒。为了抵抗噬菌体的感染，细菌进化出多种抵抗噬菌体感染的机制，这些机制的阐析极大地促进了基因编辑领域的发展，同时也为噬菌体治疗的开展奠定了基础。本文就细菌针对噬菌体感染的各个环节所进行的抵抗及其分子机制进行了简要综述，同时讨论了这些防御系统的存在对细菌自身的影响，分析了当前细菌耐受噬菌体机制研究存在的局限性，并对未来研究进行了展望。
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| 关 键 词： | 噬菌体耐受 基因编辑 超感染排斥 限制修饰系统 CRISPR系统 流产感染 噬菌体诱导性染色体岛 |
| 收稿时间： | 2021/5/31 0:00:00 |
Molecular mechanisms of bacterial resistance to bacteriophage infection: a review |
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| ZHONG Zhuojun,RAO Xiancai,LE Shuai.Molecular mechanisms of bacterial resistance to bacteriophage infection: a review[J].Microbiology,2021,48(9):3249-3260. |
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| Authors: | ZHONG Zhuojun RAO Xiancai LE Shuai |
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| Institution: | Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China |
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| Abstract: | Bacteriophage is the virus that infects bacteria. To resist bacteriophage infections, bacteria have evolved various antiviral mechanisms, which significantly promote the development of gene editing and lay down foundations for bacteriophage treatment. This review briefly concludes the molecular resistance mechanisms of host bacteria against bacteriophage infection. Next, the effects of such defense systems on bacteria physiology and ecology are discussed. Then, we summarized the limitations and future directions of bacteriophage resistance research. |
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| Keywords: | bacteriophage resistance gene editing superinfection exclusion restriction-modification systems CRISPR systems abortive infection phage-inducible chromosomal islands |
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