Indole ring binds to 7-methylguanine base by pi-pi stacking interaction. Crystal structure of 7-methylguanosine 5'-monophosphate-tryptamine complex

Strong pi-pi stacking interaction between the indole ring and 7-methylguanine base was shown by X-ray crystal analysis of the 7-methylguanosine 5'-monophosphate-tryptamine complex. This interaction appears to be strengthened by the attachment of ribose and phosphate groups to the base.