Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. |
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| Authors: | A Slominski C E Gomez-Sanchez M F Foecking J Wortsman |
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| Affiliation: | Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA. aslomin@wpo.it.luc.edu |
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| Abstract: | We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone. |
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