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Markers of cerebral damage during delirium in elderly patients with hip fracture |
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| Authors: | Barbara C van Munster Catharina M Korse Sophia E de Rooij Johannes M Bonfrer Aeilko H Zwinderman Johanna C Korevaar |
| Institution: | (1) Department of Clinical Epidemiology. Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, the Netherlands;(2) Department of Medicine, Academic Medical Centre, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, the Netherlands;(3) Department of Clinical Chemistry, Netherlands Cancer Institute, P.O. Box 90203, 1006 BE Amsterdam, the Netherlands |
| Abstract: | BackgroundS100B protein and Neuron Specific Enolase (NSE) can increase due to brain cell damage and/or increased permeability of the blood-brain-barrier. Elevation of these proteins has been shown after various neurological diseases with cognitive dysfunction. Delirium is characterized by temporal cognitive deficits and is an important risk factor for dementia. The aim of this study was to compare the level of S100B and NSE of patients before, during and after delirium with patients without delirium and investigate the possible associations with different subtypes of delirium. |
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