Mutagenesis identifies the critical amino acid residues of human endonuclease G involved in catalysis, magnesium coordination, and substrate specificity |
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| Authors: | Shih-Lu Wu Chia-Cheng Li Jaw-Chyun Chen Yi-Jin Chen Ching-Ting Lin Tin-Yun Ho Chien-Yun Hsiang |
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| Institution: | (1) Department of Biochemistry, China Medical University, Taichung, 40402, Taiwan;(2) Molecular Biology Laboratory, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, 40402, Taiwan;(3) Department of Microbiology, China Medical University, Taichung, 40402, Taiwan |
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| Abstract: | Background Endonuclease G (EndoG), a member of DNA/RNA nonspecific ββα-Me-finger nucleases, is involved in apoptosis and normal cellular
proliferation. In this study, we analyzed the critical amino acid residues of EndoG and proposed the catalytic mechanism of
EndoG. |
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