Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring |
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Authors: | Ling-Yi Wu Jain-Fang Chen Pao-Luh Tao Eagle Yi-Kung Huang |
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Institution: | (1) Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan;(2) Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Nei-Hu, Taipei, Taiwan |
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Abstract: | Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce
morphine physical dependence and tolerance in rat offspring. No evidence was presented, however, for the effect of DM co-administered
with morphine during pregnancy on morphine-induced reward and behavioral sensitization (possibly related to the potential
to induce morphine addiction) in morphine-exposed offspring. Conditioned place preference and locomotor activity tests revealed
that the p60 male offspring of chronic morphine-treated female rats were more vulnerable to morphine-induced reward and behavioral
sensitization. The administration of a low dose of morphine (1 mg/kg, i.p.) in these male offspring also increased the dopamine
and serotonin turnover rates in the nucleus accumbens, which implied that they were more sensitive to morphine. Co-administration
of DM with morphine in the dams prevented this adverse effect of morphine in the offspring rats. Thus, DM may possibly have
a great potential in the prevention of higher vulnerability to psychological dependence of morphine in the offspring of morphine-addicted
mothers. |
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Keywords: | |
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