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The electric charge of pigment granules in pigment cells
Authors:Testorf M F  Lundström I  Oberg P A
Institution:1. Department of Respiratory, The 2nd Affiliated Hospital of Kunming Medical University; Kunming, Yunnan, China;2. Department of Radiology, The 2nd Affiliated Hospital of Kunming Medical University; Kunming, Yunnan, China;3. Department of Clinical Laboratory, Yunnan Molecular Diagnostic Center, The 2nd Affiliated Hospital of Kunming Medical University, Dianmian Road, Kunming, Yunnan, China;2. Research Associate, Department of Oral Biology, University of Illinois at Chicago, Chicago, IL;3. Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Illinois at Chicago, Chicago, IL;4. Visiting Professor, Department of Orthopaedic Surgery, Rush University, Chicago, IL;5. Professor and Head, Department of Oral and Maxillofacial Surgery, University of Illinois at Chicago, Chicago, IL;1. Department of Mechanical Engineering, The Hong Kong Polytechnic University (PolyU), KLN, Hong Kong;2. Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, UK;3. Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7935, South Africa;1. Dermatology Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;2. Centre de Recherche en Cancérologie de Marseille (CRCM), Aix-Marseille University, Marseille, France;3. Inserm-U1068 (Laboratoire d''Oncologie Moléculaire), CNRS-UMR7258, Marseille, France;4. Institut Paoli-Calmettes, Marseille, France;5. Department of Pediatrics, University Medical Center Eppendorf, Hamburg, Germany;6. Mendel Laboratory, Casa Sollievo Della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy;7. IBPM, Consiglio Nazionale delle Ricerche, c/o Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy;8. Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata IDI-IRCCS, Rome, Italy;9. Genetics Section, Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy;10. Department of Medical Genetics, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;11. Institute of Human Genetics, Jena University Hospital, Jena, Germany;12. Department of Medical, Oral and Biotechnological Sciences, Gabriele D’Annunzio University of Chieti-Pescara, Chieti, Italy;13. Medical Genetics Unit, Policlinico Tor Vergata University Hospital, Rome, Italy
Abstract:Black pigment cells called melanophores change colour in response to environmental changes and have lately been studied as promising biosensors. To further elucidate the intracellular processes involved in the colour changes of these cells, and to find optimal biosensing principles, the electric charge of intracellular pigment granules, melanosomes, has been determined in vitro by electrophoresis. Melanosomes from the two extreme states in the cell colour change (aggregated and dispersed melanosomes) were measured. The charge was found to be -1.5 x 10(-16) and -1.7 x 10(-16) C, aggregated and dispersed melanosomes, respectively, without significant difference between the two conditions. This charge is of the same order of magnitude as the one of 1000 electrons. The origin of the melanosome charge, and the use of these findings in new biosensor principles, is discussed.
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