Inhibition of hepatitis B virus replication by interferon requires proteasome activity |
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| Authors: | Robek Michael D Wieland Stefan F Chisari Francis V |
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| Affiliation: | Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA. |
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| Abstract: | Hepatitis B virus (HBV) replication is inhibited in a noncytopathic manner by alpha/beta interferon (IFN-alpha/beta) and IFN-gamma. We demonstrate here that inhibitors of cellular proteasome activity can block this antiviral effect. These results suggest that a critical component of the IFN-induced antiviral response may be the proteasome-dependent degradation of viral or cellular proteins that are required for HBV replication. |
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