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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate |
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| Authors: | Macdonald S J Dowle M D Harrison L A Shah P Johnson M R Inglis G G Clarke G D Smith R A Humphreys D Molloy C R Amour A Dixon M Murkitt G Godward R E Padfield T Skarzynski T Singh O M Kumar K A Fleetwood G Hodgson S T Hardy G W Finch H |
| Affiliation: | Medicinal Chemistry 2, GlaxoWellcome Medicines Research Centre, Stevenage, UK. sjfm5947@glaxowellcome.co.uk |
| Abstract: | The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described. |
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