Department of Medicine, Columbia University, New York, NY 10032, USA.
Abstract:
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Highlights? Proapoptotic oxidative stress induces autophagy in macrophages (M?s) ? Inhibition of autophagy enhances oxidative stress and apoptosis in M?s ? Atheromata of M?-Atg5?/?Ldlr?/? mice have increased apoptosis and plaque necrosis ? Apoptotic Atg5?/? M?s are poorly recognized by phagocytes in vitro and in atheromata
