Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
Abstract:
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Highlights? Self-organization is a property of developmental systems and pluripotent stem cells. ? Tissue engineering approaches can be applied to control self-organization in vitro. ? Maturation of pluripotent stem cells in vitro may be promoted by self-organization. ? Subtle, dynamic signals are provided to pluripotent cells through self-organization.
