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Persisters: a distinct physiological state of E. coli |
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| Authors: | Devang Shah Zhigang Zhang Arkady B Khodursky Niilo Kaldalu Kristi Kurg Kim Lewis |
| Institution: | (1) Department of Biology, 134 Mugar Hall, Northeastern University, 360 Huntington Ave, 02115 Boston, MA, USA;(2) Department of Chemical Engineering and Materials Science, University of Minnesota, 55108 St Paul, MN, USA;(3) BioTechnology Institute, University of Minnesota, 55108 St Paul, MN, USA;(4) Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 55108 St Paul, MN, USA;(5) Institute of Technology, Tartu University, 50411 Tartu, Estonia |
| Abstract: | BackgroundBacterial populations contain persisters, phenotypic variants that constitute approximately 1% of cells in stationary phase and biofilm cultures. Multidrug tolerance of persisters is largely responsible for the inability of antibiotics to completely eradicate infections. Recent progress in understanding persisters is encouraging, but the main obstacle in understanding their nature was our inability to isolate these elusive cells from a wild-type population since their discovery in 1944. |
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