NBA-Palm: prediction of palmitoylation site implemented in Na?ve Bayes algorithm |
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| Authors: | Yu Xue Hu Chen Changjiang Jin Zhirong Sun Xuebiao Yao |
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| Affiliation: | (1) Laboratory of Cellular Dynamics, Hefei National Laboratory for Physical Sciences, and the University of Science and Technology of China, Hefei, 230027, China;(2) MOE Key Laboratory of Bioinformatics, State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Institute of Bioinformatics and Systems Biology, Tsinghua University, Beijing, 100084, China;(3) Department of Physiology and Cancer Research Program, Morehouse School of Medicine, Atlanta, GA 30310, USA |
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| Abstract: | Background Protein palmitoylation, an essential and reversible post-translational modification (PTM), has been implicated in cellular dynamics and plasticity. Although numerous experimental studies have been performed to explore the molecular mechanisms underlying palmitoylation processes, the intrinsic feature of substrate specificity has remained elusive. Thus, computational approaches for palmitoylation prediction are much desirable for further experimental design. |
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