MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution |
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| Authors: | Jun Wang Peter D Keightley Toby Johnson |
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| Institution: | (1) Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK |
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| Abstract: | Background Non-coding DNA sequences comprise a very large proportion of the total genomic content of mammals, most other vertebrates,
many invertebrates, and most plants. Unraveling the functional significance of non-coding DNA depends on how well we are able
to align non-coding DNA sequences. However, the alignment of non-coding DNA sequences is more difficult than aligning protein-coding
sequences. |
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