laminin alpha 1 gene is essential for normal lens development in zebrafish |
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| Authors: | Natalya S Zinkevich Dmitry V Bosenko Brian A Link Elena V Semina |
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| Institution: | (1) Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA;(2) Departments of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA;(3) Departments of Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA |
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| Abstract: | Background Laminins represent major components of basement membranes and play various roles in embryonic and adult tissues. The functional
laminin molecule consists of three chains, alpha, beta and gamma, encoded by separate genes. There are twelve different laminin
genes identified in mammals to date that are highly homologous in their sequence but different in their tissue distribution.
The laminin alpha -1 gene was shown to have the most restricted expression pattern with strong expression in ocular structures, particularly in
the developing and mature lens. |
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