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Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5 |
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| Authors: | Hubert Denise Jacqueline Poot Maribel Jiménez Audrey Ambit Daland C Herrmann Arno N Vermeulen Graham H Coombs Jeremy C Mottram |
| Affiliation: | 1. Wellcome Centre for Molecular Parasitology and Division of Infection & Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK 2. Intervet International B.V., Boxmeer, the Netherlands 3. WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain 4. Division of Cell and Molecular Biology, Imperial College London, London, SW7 2AZ, UK |
| Abstract: | BackgroundVisceral leishmaniasis caused by members of the Leishmania donovani complex is often fatal in the absence of treatment. Research has been hampered by the lack of good laboratory models and tools for genetic manipulation. In this study, we have characterised a L. infantum line (JPCM5) that was isolated from a naturally infected dog and then cloned. We found that JPCM5 has attributes that make it an excellent laboratory model; different stages of the parasite life cycle can be studied in vitro, it is accessible to genetic manipulation and it has retained its virulence. Furthermore, the L. infantum JPCM5 genome has now been fully sequenced. |
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