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High yield recombinant penicillin G amidase production and export into the growth medium using Bacillus megaterium |
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| Authors: | Yang Yang Rebekka Biedendieck Wei Wang Martin Gamer Marco Malten Dieter Jahn Wolf-Dieter Deckwer |
| Institution: | 1. Biochemical Engineering, TU-BCE, HZI-Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany 2. Institute of Microbiology, Technical University Braunschweig, Spielmannstra?e 7, D-38106, Braunschweig, Germany |
| Abstract: | BackgroundDuring the last years B. megaterium was continuously developed as production host for the secretion of proteins into the growth medium. Here, recombinant production and export of B. megaterium ATCC14945 penicillin G amidase (PGA) which is used in the reverse synthesis of β-lactam antibiotics were systematically improved. |
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