Synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring |
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Authors: | Jo Yeong Woo Im Weon Bin Rhee Jae Keol Shim Mi Ja Kim Won Bae Choi Eung Chil |
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Affiliation: | College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea. |
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Abstract: | A series of oxazolidinone derivatives, which morpholino group of linezolid was replaced with heteroaromatic ring substituted pyridine moiety, were newly synthesized, and their substituted effects on in vitro and in vivo antibacterial activities were evaluated against four problematic gram-positive strains including drug resistant strains and two gram-negative strains. Most compounds exhibited the enhanced in vitro activities with 4-16-fold and three compounds exerted more than 2-fold increased in vivo efficacies than linezolid. |
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