|
|||||
|
|
Immunogenic Properties of Peptides Mimicking a HIV-1 gp41 Epitope Recognized by Virus-Neutralizing Antibodies 2F5 |
|
| Authors: | Tumanova O. Yu. Kuvshinov V. N. Orlovskaya I. A. Pronyaeva T. R. Pokrovskii A. G. Il'ichev A. A. Sandakhchiev L. S. |
| Affiliation: | (1) Institute of Bioengineering, Vector State Research Center of Virology and Biotechnology, Kol'tsovo, Novosibirsk Region, 630559, Russia;(2) Institute of Clinical Immunology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, 630091, Russia;(3) Institute of Molecular Biology, Vector State Research Center of Virology and Biotechnology, Kol'tsovo, Novosibirsk Region, 630559, Russia |
| Abstract: | Phage display was used to obtain peptides mimicking a HIV-1 gp41 conserved epitope recognized by virus-neutralizing monoclonal antibodies (mAb) 2F5. Rabbits and mice were immunized with the peptides exposed on the surface of filamentous bacteriophages. Antibodies to gp41 were detected in the sera of immunized animals. The virus-neutralizing activity of the sera was examined. |
| Keywords: | HIV-1 neutralizing epitope of gp41 mimicking peptides phage display immunogenicity neutralizing activity |
| 本文献已被 SpringerLink 等数据库收录！ | |