Nanopore-based Fourth-generation DNA Sequencing Technology |
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Authors: | Yanxiao Feng Yuechuan Zhang Cuifeng Ying Deqiang Wang Chunlei Du |
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Institution: | Chongqing Key Laboratory of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China |
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Abstract: | Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than $100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein.Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale.In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications. |
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Keywords: | Nanopore DNA sequencing Single base Single molecule |
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