Effectivity of dolichyl phosphates with different chain lengths as acceptors of nucleotide activated sugars |
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| Authors: | P Löw E Peterson M Mizuno T Takigawa T Chojnacki G Dallner |
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| Institution: | (1) Department of Biochemistry, University of Stockholm, Stockholm, Sweden;(2) Central Research Laboratories, Kuraray Co., Ltd., Okayama, Japan;(3) Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Poland;(4) Department of Pathology, Karolinska Institutet, Stockholm, Sweden |
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| Abstract: | Chemical synthesis of different S-forms of dolichyl-P was performed in order to investigate the use of these polyprenes in mannosyl, glucosyl and glucosaminyl transferase reactions. Determination of the Vmax values for a series of dolichyl-P demonstrated that the velocities of transferase reactions with all those dolichyl-P derivatives present in animal tissues are largely the same. The apparentK
m values for the various dolichyl-P in the transferase system studied differed, but this property does not appear to have physiological importance. |
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| Keywords: | dolichyl-P glycosyl transferases microsomes |
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