Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning |
| |
Authors: | Yamamoto Shoji Oka Shogo Inoue Mitsuhiro Shimuta Misa Manabe Toshiya Takahashi Hideki Miyamoto Masaomi Asano Masahide Sakagami Junko Sudo Katsuko Iwakura Yoichiro Ono Katsuhiko Kawasaki Toshisuke |
| |
Institution: | Department of Biological Chemistry and CREST (Core Research for Educational Science and Technology) Project, Japan Science and Technology Corporation, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. |
| |
Abstract: | The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed characteristically on a series of cell adhesion molecules and is synthesized through a key enzyme, glucuronyltransferase (GlcAT-P). We generated mice with a targeted deletion of the GlcAT-P gene. The GlcAT-P -/- mice exhibited normal development of gross anatomical features, but the adult mutant mice exhibited reduced long term potentiation at the Schaffer collateral-CA1 synapses and a defect in spatial memory formation. This is the first evidence that the loss of a single non-reducing terminal carbohydrate residue attenuates brain higher functions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|