Osteoblastic differentiation and stress response of human mesenchymal stem cells exposed to alternating current electric fields |
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Authors: | Marie Hronik-Tupaj William L Rice Mark Cronin-Golomb David L Kaplan Irene Georgakoudi |
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Affiliation: | (1) Department of Biomedical Engineering, Science & Technology Center, Tufts University, 4 Colby Street, 02155 Medford, MA, USA |
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Abstract: | Background Electric fields are integral to many biological events, from maintaining cellular homeostasis to embryonic development to healing. The application of electric fields offers substantial therapeutic potential, while optimal dosing regimens and the underlying mechanisms responsible for the positive clinical impact are poorly understood. |
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