| 过硫酸化岩藻多糖硫酸酯 |
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| 引用本文： | 张连飞,宋淑亮,吉爱国. 过硫酸化岩藻多糖硫酸酯[J]. 生命的化学, 2011, 0(2) |
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| 作者姓名： | 张连飞 宋淑亮 吉爱国 |
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| 作者单位： | 山东大学威海国际生物技术研发中心;山东大学威海分校海洋学院;山东大学药学院; |
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| 摘 要： | 岩藻多糖硫酸酯(fucoidan或fucan sulfate,FS)是一种硫酸多糖,具有多种生物活性。硫酸基团对多糖活性起重要作用,并且多糖活性与硫酸基团含量呈正相关。近些年,国内外研究者对SF进行硫酸化修饰以获得高硫酸基团含量和高活性的过硫酸化岩藻多糖硫酸酯。为促进对FS硫酸化修饰的深入了解,本文对FS活性与硫酸基团含量及位置的关系、过硫酸化方法及过硫酸化岩藻多糖硫酸酯活性的研究进展进行了综述。
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| 关 键 词： | 岩藻多糖硫酸酯 硫酸基团 过硫酸化岩藻多糖硫酸酯 生物活性 |
Research progress of oversulfated fucoidan |
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| ZHANG Lianfei ,SONG Shuliang ,JI Aiguo, SDU-Weihai International Biotechnology R,D Center,Weihai ,China Marine School of Sh,ong University at Weihai,China School of Pharmaceutical Science,Sh,ong University,Jinan ,China. Research progress of oversulfated fucoidan[J]. Chemistry of Life, 2011, 0(2) |
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| Authors: | ZHANG Lianfei SONG Shuliang JI Aiguo SDU-Weihai International Biotechnology R&D Center Weihai China Marine School of Sh ong University at Weihai China School of Pharmaceutical Science Sh ong University Jinan China |
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| Affiliation: | ZHANG Lianfei 1,2,SONG Shuliang 1,JI Aiguo1,3 1 SDU-Weihai International Biotechnology R&D Center,Weihai 264029,China 2 Marine School of Shandong University at Weihai,China 3 School of Pharmaceutical Science,Shandong University,Jinan 250012,China |
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| Abstract: | Fucoidan is a kind of sulfated polysaccharide with a variety of biological activities.Sulfate plays an important role in deciding the activities of sulfated polysaccharides,and there is a significant positive correlation between sulfate content and the activities of sulfated polysaccharides.In recent years sulfation modification has been employed to obtain oversulfated fucoidans with higher sulfate content and higher activities than native fucoidans.This review discusses the relationships between activities... |
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| Keywords: | fucoidan sulfate oversulfated fucoidan biological activity |
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